Amelioration of hemodialysis-induced oxidative stress and fatigue with a hemodialysis system employing electrolyzed water containing molecular hydrogen

Abstract Background A novel hemodialysis (HD) system employing electrolyzed water containing molecular hydrogen (E-HD) has been developed to improve the bio-compatibility of HD. This study examined impact E-HD on changes in redox state during HD and HD-related fatigue. Method single-arm, prospective observational 63 patients chronic (41 males; mean age, 72 ± 9 years; median duration HD, 7 years). Redox parameters (serum myeloperoxidase [MPO], malondialdehyde-protein adduct [MDA-a], thioredoxin 1 [TRX]) were compared between control (C-HD) after 8 weeks. Fatigue was evaluated using a numerical rating scale (NRS) 8-week course. Results In C-HD, an increase serum MPO accompanied increases both oxidative products (MDA-a) anti-oxidant molecules (TRX). E-HD, although accentuated MDA-a TRX ameliorated as with C-HD. who showed fatigue (47%) change by risk factor for presence During weeks observation those displayed significant decreases scores. Conclusion ameliorates stress supports anti-oxidation suggesting improved system. may benefit fatigue, but mechanisms underlying have yet be clarified.